NEWS

NEWS

Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry

Abstract Single-cell proteomics can reveal cellular phenotypic heterogeneity and cell-specific functional networks underlying biological processes. Here, we present a streamlined workflow combining microfluidic chips for all-in-one proteomic sample preparation and data-independent acquisition (DIA) mass spectrometry (MS) for proteomic analysis down to the single-cell level. The proteomics chips enable multiplexed and automated cell isolation/counting/imaging and sample [...]
NEWS

Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor

Abstract Knowing how biomarker levels vary within biological fluids over time can produce valuable insight into tissue physiology and pathology, and could inform personalised clinical treatment. We describe here a wearable sensor for monitoring biomolecule levels that combines continuous fluid sampling with in situ analysis using wet-chemical assays (with the specific assay interchangeable depending on the target [...]
NEWS

Continuous artificial synthesis of glucose precursor using enzyme-immobilized microfluidic reactors

Introduction The world is moving rapidly into food crisis due to extreme weather, shortage of farmland, and population explosion. And glucose is the basic material of food produced by green plants using the natural photosynthesis (NPS)1. However, the NPS suffers from low-energy efficiency (~1%) and is greatly limited by soil, climate, water, and labor2,3. It [...]
NEWS

Skin-interfaced microfluidic system with personalized sweating rate and sweat chloride analytics for sports science applications

Soft wearable microfluidic patch design and sensing strategies The wearable microfluidic patch technology introduced here involves multilayered stacks of thin-film polymers that contain intricate microfluidic channels created using laser and die cutting techniques. The network of microchannels and assay wells are created using roll-to-roll processing of polymeric rolls of materials, allowing for rapid (~1000 patches/min) [...]
NEWS

Microfluidic technology for circadian studies

We designed and developed a microfluidic platform (Supplementary Fig. S7) to perform frequency-encoded metabolic perturbations, while recording circadian gene expression by luminescence detectors.

NEWS