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Jet-Printing Microfluidic Devices on Demand

There is an unmet demand for microfluidics in biomedicine. This paper describes contactless fabrication of microfluidic circuits on standard Petri dishes using just a dispensing needle, syringe pump, three-way traverse, cell-culture media, and an immiscible fluorocarbon (FC40).

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Thermofluidic chip containing virtual thermal wells

Abstract The authors describe a thermofluidic chip on which microscale islands of controlled temperature are formed within an open fluidic environment. The chip forms part of the authors’ technology for thermally controlled DNA synthesis, whereby the site-specific temperature control enables site-specific addressability of chemical reactions, for example, related to the phosphoramidite cycle. Here, the authors [...]
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Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids

Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro model to recapitulate human brain development and neurological diseases. However, the current systems for brain organoid culture require further improvement for the reliable production of high-quality organoids.

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Microfluidic platform accelerates tissue processing into single cells for molecular analysis and primary culture models

Tissues are complex mixtures of different cell subtypes, and this diversity is increasingly characterized using high-throughput single cell analysis methods. However, these efforts are hindered, as tissues must first be dissociated into single cell suspensions using methods that are often inefficient, labor-intensive, highly variable, and potentially biased towards certain cell subtypes. Here, we present a microfluidic platform consisting of three tissue processing technologies that combine tissue digestion, disaggregation, and filtration. The platform is evaluated using a diverse array of tissues. For kidney and mammary tumor, microfluidic processing produces 2.5-fold more single cells. Single cell RNA sequencing further reveals that endothelial cells, fibroblasts, and basal epithelium are enriched without affecting stress response. For liver and heart, processing time is dramatically reduced. We also demonstrate that recovery of cells from the system at periodic intervals during processing increases hepatocyte and cardiomyocyte numbers, as well as increases reproducibility from batch-to-batch for all tissues.

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Application of microfluidic chip technology in pharmaceutical analysis: A review

The development of pharmaceutical analytical methods represents one of the most significant aspects of drug development. Recent advances in microfabrication and microfluidics could provide new approaches for drug analysis, including drug screening, active testing and the study of metabolism. Microfluidic chip technologies, such as lab-on-a-chip technology, three-dimensional (3D) cell culture, organs-on-chip and droplet techniques, have all been developed rapidly. Microfluidic chips coupled with various kinds of detection techniques are suitable for the high-throughput screening, detection and mechanistic study of drugs. This review highlights the latest (2010–2018) microfluidic technology for drug analysis and discusses the potential future development in this field.

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Microfluidic enrichment of plasma cells improves treatment of multiple myeloma

Cytogenetic alterations form the basis for risk stratification for multiple myeloma (MM) and guide the selection of therapy; however, current pathology assays performed on bone marrow samples can produce false-negatives due to the unpredictable distribution and rarity of MM cells. Here, we report on a microfluidic device used to facilitate CD45 depletion to enhance the detection of cytogenetic alterations in plasma cells (PCs).

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3 key points to use CO2 incubator

The CO2 incubator mainly controls three basic variables related to living environment simulation: stable CO2 concentration, temperature, and relative humidity.   Before use CO2 incubator : The instrument should be placed on a flat working table. The working environment should be kept clean and tidy. The whole environment should be kept dry and ventilated. All [...]
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How to choose a CO2 incubator

First, you need to identify the industry in which the CO2 Incubator is being used. At present, CO2 incubators are mainly used in the following industries: hospital; 2. microbial industries; 3. pharmaceutical industries; 4. colleges and universities. Second, you need to check the environment in which the CO2 Incubator is used. In general, we need [...]
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Introduction of microfluidic fiber chip

Microfluidic fiber chips can be broadly divided into: Bilateral implantation of optical fiber Unilateral implantation of optical fiber   Bilateral implantation of optical fiber: it isn't easy to align two fiber cores precisely and perpendicular to the channel, but it can be tested by simply passing the fluorescent signal transmitted through the fiber through a [...]
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